The popularity of MDA exploded in the late 1960s, becoming such a staple of U.S. MDA never did manage to make its way into military arsenals or pharmaceutical companies’ product listings, but it did find a home in the bodies and brains of recreational drug users. Under the codename “EA-1298,” it was once even investigated as a potential interrogation drug by the U.S. In the decades after, MDA was tested by various pharmaceutical companies as a potential treatment for Parkinson’s disease, depression, obesity, and the common cough. MDA’s history began with its initial synthesis in 1910, but its psychoactivity in humans wasn’t discovered until 1930 following its first documented ingestion by American chemist Gordon Alles. While entactogenic drugs often possess some qualities of other drug classes, such as psychedelics or stimulants, they are specifically characterized by their tendency to produce feelings of closeness with others, relatedness, and emotional openness. Initially described as a unique psychedelic with an unusually powerful emotional component, MDA’s more precise classification as an entactogen didn’t occur until after the discovery of MDMA- a discovery that was partly inspired by MDA. MDA (3,4- methylene dioxy amphetamine), often called “sass,” “sassy,” or “sassafras,” is a psychoactive substance that was difficult to classify for much of its existence.
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